Translational and Precision Pharmacology

This session delves into the rapidly evolving field of translational and precision pharmacology, which bridges laboratory discoveries with clinical application to enhance drug efficacy and patient safety. The focus will be on how biological and molecular information—such as genomics, proteomics, metabolomics, and biomarker data—is integrated with pharmacokinetic and pharmacodynamic insights to tailor therapeutic strategies to individual patients. The session will explore translational approaches that link preclinical findings to human trials, highlighting the use of predictive models, in vitro–in vivo extrapolation, and physiologically based pharmacokinetic (PBPK) modeling to anticipate therapeutic outcomes and toxicity. Clinical examples will illustrate how precision pharmacology guides dose optimization, identifies patients at risk of adverse drug reactions, and enhances response prediction, particularly in areas such as oncology, immunotherapy, cardiovascular disease, and rare disorders. Speakers will discuss strategies for patient stratification, adaptive trial design, and biomarker-driven therapy, emphasizing the practical application of biological insights to improve clinical decision-making. Emerging tools, including artificial intelligence, machine learning, and systems pharmacology, will be highlighted for their role in integrating complex biological datasets to inform individualized therapy. Ethical, regulatory, and implementation challenges associated with precision pharmacology will also be addressed, including data interpretation, patient privacy, and accessibility. By combining foundational biological understanding with advanced analytical and clinical approaches, this session aims to demonstrate how translational and precision pharmacology transforms therapeutic practice, minimizes adverse effects, and maximizes the therapeutic benefit for diverse patient populations.

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