Genetic and Molecular Toxicology

This session delves into genetic and molecular toxicology, focusing on how toxic agents interact with cellular and molecular pathways to induce DNA damage, gene mutations, chromosomal alterations, and epigenetic changes that can lead to disease, cancer, or heritable effects. Emphasis will be placed on understanding the biological mechanisms underlying genotoxicity, including oxidative stress, DNA adduct formation, and disruption of repair mechanisms, as well as the role of cellular signaling pathways in mediating toxicity. Participants will learn how genetic variability, polymorphisms, and epigenetic modifications influence individual susceptibility to toxic exposures and drug-induced adverse effects. The session will cover state-of-the-art methods for assessing molecular toxicity, including in vitro assays, high-throughput screening, omics technologies, and biomarker identification, highlighting their application in drug development, risk assessment, and regulatory decision-making. Real-world case studies will illustrate the translation of molecular toxicology findings to clinical and public health outcomes, including strategies to predict, prevent, and mitigate toxic effects. The role of computational modeling and bioinformatics in analyzing complex biological data will also be discussed, providing insight into mechanistic pathways and exposure-response relationships. Ethical, regulatory, and safety considerations in applying molecular toxicology findings will be emphasized, particularly in personalized medicine and precision pharmacology. By integrating molecular biology, pharmacology, and toxicology, this session aims to equip participants with a comprehensive understanding of how toxic agents affect genetic material, how these effects can be monitored and mitigated, and how molecular insights contribute to safer drug design, regulatory compliance, and improved patient outcomes.

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