Neurotoxicology and Immunotoxicology

This session explores neurotoxicology and immunotoxicology, focusing on how chemical agents, drugs, environmental toxins, and biologics impact the nervous and immune systems, influencing both acute and chronic health outcomes. The session will examine the biological mechanisms underlying neurotoxicity, including oxidative stress, excitotoxicity, mitochondrial dysfunction, and disruption of neurotransmission, as well as immune system toxicity through altered cytokine signaling, hypersensitivity reactions, and immune suppression. Participants will learn how genetic, developmental, and physiological factors influence susceptibility to neurotoxic and immunotoxic effects, highlighting vulnerable populations such as children, the elderly, and immunocompromised individuals. The session will cover preclinical models, in vitro assays, and biomarker-based approaches used to detect, monitor, and predict toxicity, as well as clinical evaluation strategies for assessing neurological and immunological adverse events. Case studies will illustrate real-world examples, including drug-induced neurotoxicity, vaccine-related immune reactions, environmental neurotoxins, and occupational exposures, emphasizing strategies to prevent, mitigate, and manage toxic outcomes. Regulatory, ethical, and safety considerations will be addressed, including guidelines for risk assessment, pharmacovigilance, and clinical monitoring. Emerging technologies, such as high-throughput screening, omics approaches, neuroimaging, and computational modeling, will be discussed for their role in advancing mechanistic understanding and improving predictive accuracy. By integrating biological, clinical, and regulatory perspectives, this session aims to equip participants with the knowledge, tools, and strategies to identify, prevent, and manage neurotoxic and immunotoxic effects, ensuring patient safety and advancing therapeutic innovation.

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