Therapeutic Drug Monitoring

This session focuses on the critical practice of therapeutic drug monitoring (TDM), which involves measuring drug concentrations in biological fluids to optimize individual patient therapy, enhance therapeutic benefits, and minimize adverse effects. The session will highlight how pharmacokinetic and pharmacodynamic principles guide TDM, emphasizing the role of biological factors such as metabolism, organ function, age, genetics, and comorbidities in influencing drug levels and response. Clinical case studies will illustrate situations where TDM is essential, including drugs with narrow therapeutic windows, significant interindividual variability, or high toxicity potential, such as antiepileptics, immunosuppressants, anticoagulants, and certain antibiotics. Participants will learn how integrating laboratory measurements with patient-specific biological information allows for personalized dose adjustment, early detection of toxicity, and improved efficacy. The session will also explore the latest analytical technologies, including high-performance liquid chromatography, mass spectrometry, and point-of-care testing, which facilitate accurate and timely monitoring. Emerging trends such as model-informed precision dosing, pharmacogenetic-guided TDM, and integration with electronic health records will be discussed, demonstrating how advanced approaches enhance clinical decision-making. Ethical and regulatory considerations, along with practical challenges in implementing TDM programs in hospitals and clinics, will also be covered. By connecting biological insights with real-world therapeutic outcomes, this session aims to equip participants with the knowledge and tools necessary to optimize drug therapy, prevent adverse events, and support personalized medicine in routine clinical practice.

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