Clinical Pharmacokinetics and Pharmacodynamics

This session focuses on the fundamental principles and clinical applications of pharmacokinetics (PK) and pharmacodynamics (PD), emphasizing how drugs are absorbed, distributed, metabolized, and eliminated in the human body, and how these processes influence therapeutic response and safety. The session will explore the biological and physiological factors that govern drug concentration–time profiles and their relationship to pharmacological effects, therapeutic benefits, and adverse outcomes. Special attention will be given to interindividual variability arising from genetic makeup, age, sex, organ function, disease states, and environmental influences. Speakers will discuss how PK/PD modeling and simulation are used to optimize dose selection, improve efficacy, and minimize side effects across different patient populations. The session will also address the role of biomarkers and biological data in predicting drug response and toxicity, enabling more precise and personalized treatment strategies. Clinical case studies will highlight how altered pharmacokinetics can lead to subtherapeutic effects or increased risk of toxicity, underscoring the importance of therapeutic drug monitoring and dose individualization. In addition, emerging approaches such as population pharmacokinetics, physiologically based pharmacokinetic (PBPK) modeling, and exposure–response analysis will be examined for their impact on drug development and regulatory decision-making. By integrating biological information with clinical outcomes, this session aims to enhance understanding of the balance between drug benefits and side effects, ultimately supporting safer, more effective, and evidence-based use of medicines in clinical practice.

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